Two-dimensional (2D) materials, such as graphene, transition metal dichalcogenides (TMDs), and MXenes, have garnered significant attention due to their remarkable mechanical, electronic, and thermal properties. However, their application potential in diverse fields, including electronics, energy, and biomedicine, is closely linked to their stability under biological and environmental conditions. Understanding the degradation behavior of 2D materials is critical to ensuring their reliable and sustainable use. Biological Degradation: When exposed to biological environments, 2D materials interact with biomolecules, enzymes, and cells, leading to structural and chemical changes. For example, graphene oxide and TMDs may undergo oxidation or enzymatic degradation when exposed to reactive oxygen species (ROS) or specific enzymes like myeloperoxidase. These interactions can alter their morphology, electrical conductivity, and surface chemistry, potentially limiting their long-term biocompatibi...
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